Aogebio Cosmetic
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Mechanism of Action: Acetyl Tetrapeptide-22 is a biomimetic tetrapeptide specifically designed to target the primary causes of under-eye puffiness and dark circles. Its mechanism is multi-faceted and grounded in cellular physiology.
Targeting Periorbital Puffiness (Edema): The peptide acts on the Vanillin Receptor Type 1 (VR1/TRPV1), which is involved in vascular permeability. By modulating this receptor, it reduces capillary hyperpermeability (leaky capillaries), preventing fluid accumulation in periorbital tissue.
Improving Dark Circles: By stabilizing capillaries and reducing leakage, it minimizes the seepage of red blood cells, subsequently reducing the breakdown of hemoglobin and deposition of pigmented byproducts.
Anti-Inflammatory Action: Inhibits the release of pro-inflammatory mediators, helping to reduce swelling and discoloration.
Effectively acts as an antagonist on the TRPV1 receptor, confirming its proposed mechanism for reducing vascular leakage.
Significantly decreases VEGF-induced hyperpermeability, validating its ability to "tighten" capillary walls.
30% improvement in under-eye bag volume and visible lightening of dark circles over a 56-day study (5% solution applied twice daily).
Excellent topical safety. Non-irritating, non-sensitizing, and non-cytotoxic. Safe for delicate eye contour area.
As a biomimetic peptide, it is exceptionally well-tolerated by the skin.
Highly soluble and stable in aqueous phases. Compatible with caffeine, vitamin K, and various emulsion systems across a broad pH range.
It is a specialized biomimetic peptide designed to reduce under-eye puffiness (bags) and dark circles by targeting vascular permeability and inflammation.
The peptide acts as an antagonist on the TRPV1 receptor. This helps "tighten" capillary walls and reduces fluid leakage into the surrounding tissue, which is the root cause of puffiness.
The clinically effective concentration is typically 5 ppm (0.0005%) of the pure peptide. Depending on the formulation goals, usage ranges from 2 to 10 ppm.
Yes, it is highly stable and compatible with a wide range of ingredients including caffeine, Vitamin K, other anti-aging peptides, and standard emulsion systems.
In clinical studies, significant reductions in eye bag volume (up to 30%) and visible lightening of dark circles were measured over a 56-day period with twice-daily application.
Yes, it is a vegan-friendly biomimetic peptide. Extensive testing has shown it to be non-irritating and non-sensitizing, making it ideal for the delicate skin around the eyes.
