Product Description
MOA (Mechanism of Action)
Tripeptide-1, with the amino acid sequence Gly-His-Lys (GHK), is a naturally occurring human peptide that plays a fundamental role in tissue repair and regeneration. Its mechanism revolves around reprogramming aged or damaged cells to a healthier, more youthful state.
- Cell Communication: GHK acts as a signal peptide, binding to specific receptors on fibroblasts and keratinocytes to trigger repair pathways.
- Tissue Repair Genes: Positively modulates gene expression for structural proteins (Collagen I, III, IV, and Decorin).
- Immune Attraction: Acts as a chemoattractant for repair cells to accelerate natural healing.
- Antioxidant Activity: Protects skin from oxidative stress and reduces inflammatory cytokines.
In Vitro Efficacy Data
Collagen Synthesis: Increases collagen synthesis by up to 150%.
GAG Production: Boosts hyaluronic acid production for hydration and volume.
Cell Proliferation: Enhances migration of fibroblasts essential for wound healing.
Clinical Results
Texture & Wrinkles: Significant improvements in firmness and reduction in fine lines after 4-12 weeks.
Wound Healing: Proven to accelerate tissue organization and improve scar appearance.
Skin Brightening: Enhances clarity and tone through anti-inflammatory properties.
Safety & Compatibility
Safety Profile: Biocompatible and biomimetic. Non-toxic, non-irritating, and suitable for sensitive skin types.
Synergistic Combinations: Works perfectly with Copper (to form GHK-Cu), Matrixyl, Growth Factors, and Antioxidants (Vitamin C, E).
Formulation Stability: Stable in aqueous solutions within a pH range of 4.0 to 7.0.
Recommended Dosage & Formulations
Usage Level: 1 - 10 ppm (0.0001% - 0.001%). Potent signaling molecule effective at very low concentrations.
Suitable For:
- Serums and Ampoules (Regenerative & Anti-aging)
- Creams and Lotions
- Post-Procedure Treatments & Wound Healing
- Scalp and Hair Care (Follicle stimulation)
Summary & Key Selling Points
Storage: Dry Place / RT
Cruelty Free
100% Vegan
Non-GMO
Frequently Asked Questions
What exactly is Tripeptide-1?
Tripeptide-1, also known as GHK, is a biomimetic signal peptide naturally found in human plasma. It serves as a messenger to reprogram skin cells towards repair and rejuvenation.
Is Tripeptide-1 the same as GHK-Cu?
Tripeptide-1 is the base peptide. When combined with Copper, it becomes GHK-Cu (Copper Tripeptide-1). Tripeptide-1 itself is the fundamental building block responsible for the repair signaling.
What is the recommended dosage for effective results?
Due to its high biological activity, a very low concentration of 1 - 10 ppm (0.0001% - 0.001%) is sufficient to trigger cellular repair and collagen synthesis.
Can it be used on sensitive or post-procedure skin?
Yes. Being a naturally occurring peptide fragment in the human body, it is exceptionally safe, non-irritating, and often used in medical-grade post-procedure healing formulations.
How does it benefit anti-aging formulations?
It stimulates the synthesis of Collagen I, III, and IV, boosts hyaluronic acid production, and improves overall skin elasticity and firmness while reducing fine lines.
Is this ingredient vegan and cruelty-free?
Yes, this Tripeptide-1 is vegan-friendly as it does not contain animal-derived components and has not been tested on animals.
Aogebio Cosmetic
