Product Description
1. Mechanism of Action (MOA)
Tripeptide-32 is a biomimetic peptide specifically designed to enhance the skin's innate adaptive response to environmental stressors. Its mechanism is inspired by the body's natural cellular defense systems.
- Activation of Cytoprotective Pathways: Functions by upregulating the expression of protective Heat Shock Proteins (HSPs).
- Key Regulator: Modulates the activity of Heat Shock Factor 1 (HSF1), the primary transcription factor for the heat shock response.
- Cellular Defense Enhancement: Helps cells withstand and recover from damage caused by UV Radiation, Blue Light (HEV), Oxidative Stress, Pollution, and Thermal Stress.
- Overall Effect: Strengthens cellular resilience, reduces oxidative damage, inhibits inflammation, and prevents premature aging.
2. In-Vitro Efficacy Data
Model: Human epidermal keratinocytes and dermal fibroblasts.
- HSF1 Activation: Demonstrated significant increase in activation.
- Heat Shock Protein Expression: Dose-dependent increase in HSP70 expression (over 2.5-fold).
- Protection against Oxidative Stress: ~40% increase in cell viability after hydrogen peroxide exposure.
- Anti-Inflammatory Effect: Marked reduction in pro-inflammatory cytokines (IL-6) following UV exposure.
3. Clinical Results
12-week, double-blind, placebo-controlled study on female volunteers (aged 30-55) using 5 ppm Tripeptide-32 twice daily.
25% Improvement
Skin clarity and evenness, with reduction in hyperpigmentation.
18% Reduction
Appearance of fine lines and wrinkles (eyes and forehead).
20% Increase
Skin hydration and improved barrier function.
Subject Assessment: 88% reported healthier, more radiant, and less fatigued skin.
Recommended Usage & Dosage
Recommended Dosage: 3 - 10 ppm (0.0003% - 0.001%)
Optimal Efficacy: 5 ppm is recommended for significant clinical benefits.
Suggested Product Forms
🛡️ Defense Serums
☀️ Day Creams
🏖️ Post-Sun Care
👁️ Eye Creams
Frequently Asked Questions
What is the main function of Tripeptide-32?
Tripeptide-32 is a biomimetic peptide that activates the skin's internal defense system by upregulating Heat Shock Proteins (HSPs) to protect cells from environmental damage.
Does it protect against Blue Light?
Yes, Tripeptide-32 is clinically proven to enhance cellular resilience against High-Energy Visible (HEV) light, also known as Blue Light, as well as UV radiation and pollution.
What is the recommended dosage for skincare formulations?
The recommended dosage is between 3 to 10 ppm (0.0003% - 0.001%). For optimal clinical benefits, 5 ppm is suggested.
Is Tripeptide-32 compatible with other active ingredients?
Yes, it works synergistically with antioxidants like Vitamin C and E, as well as sunscreen filters and other repair peptides like Matrixyl.
Is this product suitable for sensitive skin?
Yes, Tripeptide-32 has an excellent safety profile. It is non-irritating, non-sensitizing, and hypoallergenic, making it suitable for all skin types.
Is Tripeptide-32 a vegan-friendly ingredient?
Yes, the product does not contain any animal-derived components and is considered vegan-friendly.
Aogebio Cosmetic
