OEM Tetrapeptide-21 Soothing Peptide For Sensitive Skin Care Manufacturers, Supplier

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OEM Tetrapeptide-21 Soothing Peptide For Sensitive Skin Care Manufacturers, Supplier

Products Name	Â Tetrapeptide-21
CAS No	Â 960608-17-7
INCI Name	Â Tetrapeptide-21
Specification	Â â‰¥95% (HPLC)
Molecular Weight	Â 406.4 g/molÂ
Chemical Formula	Â Câ‚â‚‡Hâ‚ƒâ‚€Nâ‚ˆOâ‚… (free base)
Appearance	Â White to off-white powder
Solubility	Â Soluble in water

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Product Description

Mechanism of Action (MOA)

Tetrapeptide-21 is an innovative neurocosmetic peptide that specifically targets the underlying causes of skin sensitivity and irritation through a neuromodulatory pathway.

Inhibition of Neurogenic Inflammation:

Specific antagonist of the Mas-related G-protein-coupled receptor X4 (MRGPRX4).
Prevents the release of key neuropeptides, such as Substance P.
Reduces vasodilation (redness) and plasma extravasation (swelling).

Calming Sensory Neurons:

Reduces the hyper-reactivity of sensory neurons, lowering overreaction to external aggressors like pollutants or physical stress.

In Vitro & Clinical Results

In Vitro Efficacy

High binding affinity for the MRGPRX4 receptor. Studies show significant inhibition of Substance P release and reduced production of pro-inflammatory cytokines.

Clinical Study

A 28-day study on sensitive skin volunteers using 50 ppm Tetrapeptide-21 twice daily showed a significant decrease in stinging, itching, and burning.

Visible Redness

Clinical grading confirmed statistically significant reduction in facial redness and overall skin reactivity.

Safety & Compatibility

Safety Profile

Non-irritating, non-sensitizing, and non-cytotoxic.

Biocompatibility

Biomimetic peptide, exceptionally well-tolerated.

Formulation

Highly soluble and stable in aqueous phases.

Recommended Usage & Dosage

Concentration: 20 to 100 ppm (0.002% - 0.01%).

Clinical Dosage: 50 ppm (0.005%) is proven effective for soothing and anti-redness effects.

Applications: Calming serums, anti-redness creams, pre/post-procedure care, after-shave, and boosters for retinoid tolerance.

Summary & Key Selling Points

Targeted Neurocosmetic Action: Directly inhibits neurogenic inflammation via MRGPRX4.

Rapid Soothing: Quick relief from stinging, itching, and burning sensations.

Reduces Redness: Clinically proven to decrease visible skin reactivity.

Boosts Tolerance: Strengthens resilience against environmental stressors.

Science-Backed: Cutting-edge pathway in modern dermatology.

Safe & Vegan: Non-animal tested and highly biocompatible.

Storage
Dry place, Room Temp

Testing
No Animal Testing

Vegan
Plant/Synthetic Origin

GMO
Non-GMO

Frequently Asked Questions

Q1: What is the main benefit of Tetrapeptide-21 for the skin? A: It primarily acts as a neurocosmetic soothing agent that reduces skin sensitivity, redness, and discomfort like itching or stinging.

Q2: How does it help with skin redness? A: By blocking the MRGPRX4 receptor, it inhibits the release of neuropeptides that cause vasodilation, thereby reducing visible redness.

Q3: What is the recommended concentration for cosmetic formulations? A: The typical use level is 20-100 ppm, with 50 ppm (0.005%) being the clinically recommended dosage for optimal results.

Q4: Can this peptide be used in products with Retinol or Vitamin C? A: Yes, it is excellent for boosting skin tolerance, making it ideal to use alongside potentially irritating actives like retinoids or acids.

Q5: Is Tetrapeptide-21 water-soluble? A: Yes, it is highly soluble and stable in aqueous phases, making it easy to incorporate into serums and creams.

Q6: Is this product suitable for vegan formulations? A: Yes, Tetrapeptide-21 does not contain animal-derived components and is not tested on animals.