Product Description
MOA - Mechanism of Action
Myristoyl Tripeptide-31 is a biomimetic peptide renowned for its potent anti-inflammatory and skin-conditioning properties. Its mechanism is highly specific and plays a crucial supportive role in multi-peptide complexes.
Primary Anti-Inflammatory and Immunomodulatory Action
The core function of Myristoyl Tripeptide-31 is to downregulate the skin's inflammatory response. It achieves this by specifically targeting and inhibiting key pro-inflammatory cytokines, most notably Interleukin-6 (IL-6) and other mediators.
By calming this cytokine activity, it effectively reduces skin redness, sensitivity, and the underlying inflammatory processes that can accelerate skin aging and impair barrier function.
Synergistic Role in Peptide Complexes
Myristoyl Tripeptide-31 is a fundamental component of the famous Palmitoyl Tetrapeptide-7 complex. It provides the "calming foundation" that allows other collagen-stimulating peptides (like Palmitoyl Tripeptide-1) to work more effectively. By reducing background inflammation, the skin is in a more optimal state for repair and regeneration.
Barrier Support
Through its anti-inflammatory action, it indirectly contributes to a healthier, more resilient skin barrier, reducing reactivity and transepidermal water loss (TEWL). The Myristoyl (C14) chain enhances the lipophilicity and skin penetration of the peptide, ensuring it reaches its target sites in the viable epidermis.
In Vitro Efficacy Data
- Cytokine Inhibition Assays: Studies demonstrated reduction of IL-6 secretion by over 50% under inflammatory stimuli.
- Cell Protection: Helps protect fibroblasts and keratinocytes from inflammatory damage.
- Gene Expression Analysis: Confirmed role in modulating genes involved in the inflammatory cascade.
Clinical Results
Reduction of Irritation
Significant reduction in visible redness and stinging sensation compared to placebo. Assessment confirms improved skin comfort and a calmer complexion.
Enhanced Anti-Aging
When combined with Palmitoyl Tripeptide-1, it demonstrates superior results in reducing wrinkle depth and volume compared to single peptides.
Safety & Compatibility
Safety Profile: Excellent profile; non-irritating, non-sensitizing, and exceptionally well-tolerated by all skin types.
Compatibility & Synergy: Works powerfully with Collagen-Stimulating Peptides, Retinol, AHAs, Vitamin C, Niacinamide, and Hyaluronic Acid.
Recommended Dosage & Formulation
Recommended Usage Level: Typically used as part of a peptide complex at 2% to 5% in the final formulation.
Recommended Formulations:
- Anti-Aging Serums & Creams
- Sensitive Skin Formulas
- Pre/Post-Procedure Care
- Eye Creams
Summary Selling Points
The Strategic Soother: Targeted anti-inflammatory action by inhibiting IL-6.
Force Multiplier: Vital component of Matrixyl 3000 for synergistic collagen boosting.
High-Performance Enabler: Reduces irritation risk for potent actives like Retinol.
Clinically Validated: Proven visible reduction in redness and comfort improvement.
Storage: Closed container, dry place, room temperature.
Animal Testing: Not animal tested.
Vegan: No animal-derived components.
GMO: No data available.
Frequently Asked Questions
Q1: What is the primary function of Myristoyl Tripeptide-31?
A: Its core function is to downregulate the skin's inflammatory response by inhibiting key cytokines like IL-6, which helps reduce redness and sensitivity.
Q2: How does it help in anti-aging formulations?
A: It acts as a "calming foundation" that allows collagen-stimulating peptides to work more effectively, leading to superior wrinkle reduction and skin repair.
Q3: Is it safe for sensitive skin?
A: Yes, it is non-irritating, non-sensitizing, and clinically proven to improve skin comfort and reduce visible redness in sensitive skin populations.
Q4: Can it be combined with Retinol or Vitamin C?
A: Absolutely. It acts as a built-in buffer to reduce the potential irritation often associated with potent actives like Retinol and AHAs.
Q5: What is the recommended usage dosage?
A: It is typically used at a concentration of 2% to 5% within a peptide complex in the final cosmetic formulation.
Q6: Is Myristoyl Tripeptide-31 vegan and cruelty-free?
A: Yes, it does not contain animal-derived components and has not been tested on animals.
Aogebio Cosmetic
