Custom Myristoyl Pentapeptide-17 Intensive Wrinkle Smoothing & Firming Treatment Factories, Company

Products Name Myristoyl Pentapeptide-17
CAS No 959610-30-1
INCI Name Myristoyl Pentapeptide-17
Specification ≥95% (HPLC)
Molecular Weight 675.88 g/mol
Chemical Formula C₃₂H₅₇N₇O₇ 
Appearance White to off-white fine powder
Solubility Soluble in water and aqueous solutions; recommended to dissolve in water or glycerin.

Product Description

Product Overview

Product Description

1. MOA (Mechanism of Action)
Myristoyl Pentapeptide-17 is a synthetic, biomimetic peptide designed to target the appearance of skin aging by supporting the dermal-epidermal junction (DEJ) and extracellular matrix (ECM).

Dermal-Epidermal Junction (DEJ) Reinforcement

The peptide sequence is engineered to mimic the activity of natural proteins that are crucial for the structural integrity of the DEJ. By signaling dermal cells, it helps to promote the synthesis of key DEJ components such as Collagen IV, Collagen VII, and Laminin V.

Extracellular Matrix (ECM) Support

It provides a supportive signal to fibroblasts, leading to an increased production of major dermal structural proteins, including Collagen I, III, and Elastin, resulting in improved skin density and elasticity.

Enhanced Bioavailability

The myristoyl (C14) lipid chain attached to the peptide enhances its skin penetration and stability, allowing it to effectively reach its target sites within the dermis.

In Vitro Efficacy Data

1
Gene Expression Analysis (PCR):

Demonstrates a significant upregulation of genes encoding for Collagen I, III, IV, VII, and Laminin 5.

2
Collagen Protein Synthesis Assay:

A dose-dependent increase in the production of Collagen I and III proteins is observed in cell culture.

3
Fibroblast Proliferation Assay:

Shows a stimulatory effect on fibroblast metabolism, enhancing the skin's natural regenerative capacity.

Clinical Results

A 12-week, double-blind, placebo-controlled study with female volunteers aged 40-65 applying a 4% Myristoyl Pentapeptide-17 serum showed:

  • Cutometry: Improvement in skin elasticity and firmness (up to 18% increase).
  • Profilometry: Significant reduction in depth and volume of wrinkles, particularly in the crow's feet area.
  • Clinical Grading: Visible improvement in overall skin firmness and a lifting effect on facial contours.
  • Self-Assessment: Over 85% of participants reported firmer and more youthful-looking skin.
  • Excellent Tolerance: Non-irritating and suitable for all skin types, including sensitive skin.

Safety & Compatibility

Safety Profile PH Compatibility Formulation Compatibility
Safety Profile

Non-irritating, non-cytotoxic, and highly biocompatible ingredient.

pH Compatibility

Effective in a wide pH range, ideally between 4.5 and 7.0.

Formulation Tips

Synergistic with Hyaluronic Acid, Niacinamide, and Vitamin C. Recommended to incorporate into the water phase at temperatures <40°C.

Usage Guidance

Recommended Usage & Dosage

Usage Level: 2% - 5% in final formulation.
Serums & Ampoules
Firming Creams & Lotions
Lifting & Contouring Gels
Eye Creams

Summary & Key Selling Points

DEJ Action Clinical Effect Biomimetic
Targeted DEJ & ECM Action: Multi-layered skin firming.
Clinically Proven Lifting: Visible reduction in sagging signs.
Biomimetic & Safe: Ideal for sensitive skin.
Superior Penetration: Myristoyl modification for optimal efficacy.
Storage Storage: Dry place, Room temp
No Animal Testing Not animal tested
Vegan Vegan Friendly
GMO GMO Free

Frequently Asked Questions

What is Myristoyl Pentapeptide-17?
It is a synthetic biomimetic peptide modified with a lipid chain to enhance skin penetration, specifically designed to stimulate collagen production and improve skin firmness.
How does it work on wrinkles?
It targets the Dermal-Epidermal Junction (DEJ) and the Extracellular Matrix (ECM) to boost the synthesis of Collagen I, III, IV, VII, and Elastin, which helps fill in wrinkles from within.
What is the recommended concentration for formulations?
For optimal clinical results, a usage level between 2% and 5% is recommended in final products such as serums and creams.
Is this ingredient suitable for sensitive skin?
Yes, clinical studies show it is highly biocompatible, non-irritating, and well-tolerated even by those with sensitive skin.
How should it be handled during manufacturing?
It is stable in aqueous solutions but should be added during the water phase at temperatures below 40°C to maintain its biological activity.
Is it vegan and cruelty-free?
Yes, it does not contain animal-derived components and has not been tested on animals.

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