Custom Cosmetic Grade Decarboxy Carnosine Hydrochloride (≥98%) Company, Exporter

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Custom Cosmetic Grade Decarboxy Carnosine Hydrochloride (≥98%) Company, Exporter

Products Name	Decarboxy carnosine hydrochloride
CAS No	57022-38-5
INCI Name	Decarboxy carnosineÂ
Specification	Â â‰¥98% (HPLC)
Molecular Weight	Â 234.70 g/mol
Chemical Formula	Câ‚‰Hâ‚â‚…ClNâ‚„O
Appearance	White to off-white crystalline powder
Solubility	Freely soluble in water

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Product Description

1. Mechanism of Action (MOA)

Decarboxy Carnosine Hydrochloride is a stabilized derivative of L-carnosine with enhanced bioavailability and cellular penetration. Its primary mechanisms include:

Advanced Glycation End-products (AGEs) Inhibition
Acts as a potent carbonyl quencher, neutralizing reactive dicarbonyl species (e.g., methylglyoxal, glyoxal) that drive protein cross-linking and AGEs formation. Protects collagen and elastin fibers from glycation-induced stiffness and yellowing.

Mitochondrial Protection
Reduces glycative and oxidative stress in mitochondria, preserving cellular energy production and delaying senescence.

Anti-Inflammatory Activity
Suppresses NF-κB pathway activation and downstream pro-inflammatory cytokines (e.g., IL-6, TNF-α).

2. In Vitro Efficacy Data

AGEs Inhibition: 92% reduction in methylglyoxal-induced collagen glycation at 0.05 mM.
Carbonyl Quenching Capacity: 4.5-fold higher than L-carnosine in glycation simulation models.
Collagen Protection: 80% decrease in fluorescent AGEs formation in human dermal fibroblasts.
Cellular Viability: 40% reduction in ROS levels under glycative stress.

Clinical Results

Study Design: 8-week randomized trial on 50 subjects (35–60 years) using a cream containing 1.5% Decarboxy Carnosine HCl.

📈 Skin Elasticity

21% improvement (cutometer R7 parameter).

✨ Wrinkle Depth

28% reduction in periocular wrinkles by 3D image analysis.

🛡️ Skin Clarity

Significant decrease in yellowing (ΔITA° = +7.5).

Hydration: 18% increase in corneometer values. Subject Feedback: 88% reported improved skin firmness and brightness.

Safety & Compatibility

Safety Profile

Non-irritating (HRIPT certified), non-comedogenic, and suitable for sensitive skin.

Formulation Compatibility

Stable at pH 4.5–7.5. Compatible with antioxidants (vitamin C, E), niacinamide, hyaluronic acid, and most peptide blends. Avoid strong oxidizing/reducing agents and highly alkaline conditions (>pH 8.0).

Recommended Usage & Dosage

Use Level: 1–3% in final product.
Optimal Dose: 1.5–2% for significant anti-glycation and anti-aging benefits.
Recommended Applications: Anti-glycation serums and creams, Mature skin treatments, Brightening and radiance-boosting formulations, Preventive aging products.

Summary & Key Selling Points

Enhanced Bioavailability

Potent Anti-Glycation

Multi-Modal Anti-Aging

Clinically Validated

Storage

Store in a closed container at a dry place at room temperature.

Animal Testing

Not animal tested.

Vegan

Does not contain animal-derived components.

GMO

No data available.

Frequently Asked Questions

What is the recommended dosage for Decarboxy Carnosine HCl?

The recommended usage level is 1–3% in the final product. For significant anti-glycation and anti-aging benefits, an optimal dose of 1.5–2% is suggested.

Is it stable in common skincare formulations?

Yes, it is highly stable within a pH range of 4.5–7.5 and is compatible with most active ingredients like vitamin C, vitamin E, niacinamide, and hyaluronic acid.

How does it differ from traditional L-carnosine?

It is a stabilized derivative with significantly higher bioavailability and cellular penetration. It offers 4.5-fold higher carbonyl quenching capacity than traditional L-carnosine.

What are the main benefits for aging skin?

It targets skin yellowing, loss of elasticity, and wrinkles by inhibiting Advanced Glycation End-products (AGEs) and protecting mitochondrial energy.

Is this ingredient suitable for vegan products?

Yes, it does not contain any animal-derived components and has not been tested on animals.

Does it help with sensitive skin?

Yes, clinical data indicates it is non-irritating (HRIPT certified) and non-comedogenic, making it suitable for sensitive skin types.