Custom Iscotrizinol Manufacturer & Exporter

Premium Grade Diethylhexyl Butamido Triazone (DBT) | High-Performance UV-B Photoprotection for Advanced Suncare Formulations

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Industry Whitepaper

Global Industrial Status & Technical Breakdown of Iscotrizinol

Iscotrizinol, chemically known as Diethylhexyl Butamido Triazone (DBT), represents the vanguard of photostable, oil-soluble chemical UV filters. In an era where consumer awareness is shifting dynamically toward long-lasting, reef-safe, and skin-friendly formulations, Iscotrizinol has emerged as the definitive ingredient for high-protection sunscreens. With a molecular structure designed for remarkable oil-solubility and extremely low skin penetration, it addresses both formulation stability and dermatological safety.

Unlike traditional chemical filters such as Avobenzone, which undergoes significant photo-degradation under UV light unless heavily stabilized, Iscotrizinol displays exceptional photostability. It loses less than 10% of its SPF protection capability after 25 hours of intense UV exposure. This characteristic, combined with its high specific extinction coefficient in the UV-B region (around 310 nm), enables cosmetic formulators to develop high-SPF products using lower concentrations of active ingredients, thereby minimizing the risk of skin sensitization.

Global Regulatory Landscapes & Market Demand Dynamics

The regulatory framework governing cosmetic ingredients varies across key geographical territories, dictating the global demand for Iscotrizinol:

  • European Union (EU): Iscotrizinol is approved for use in cosmetics at concentrations of up to 10% under Annex VI of the EU Cosmetics Regulation. Its high molecular weight (approximately 766 g/mol) prevents systemic absorption, aligning with the EU's strict consumer safety guidelines.
  • Asia-Pacific (APAC) & China: Approved in major cosmetics hubs including China, Japan, and South Korea. In China's cosmetic raw material catalog, DBT is recognized as an efficient and safe UV filter, widely used in premium domestic and export sunscreen products.
  • North America (US FDA): Currently undergoing evaluation under the OTC Sunscreen Monograph process. While not yet widely integrated into US OTC formulations, international brands utilize US-compliant alternatives or export DBT-formulated products to non-US markets where regulatory approvals are fully realized.
Technical Parameter Specification / Detail
INCI Name Diethylhexyl Butamido Triazone (DBT) / Iscotrizinol
CAS Number 154702-15-5
Molecular Formula C44H59N7O5
Molecular Weight 766.0 g/mol
Appearance White to pale yellow crystalline powder
Specific Extinction (E1%, 1cm) Min. 1,500 at 310 nm
Purity (HPLC) ≥ 99.0%

Understanding the Synergistic Power of Iscotrizinol in Advanced Formulations

In modern sun care development, relying on a single UV filter is insufficient to achieve broad-spectrum protection (UV-A + UV-B) and meet rigorous critical wavelength requirements. Iscotrizinol is exceptionally effective when combined with UV-A absorbers such as Avobenzone (Butyl Methoxydibenzoylmethane) or Bemotrizinol (Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine). When paired together, Iscotrizinol acts as a photostabilizer for Avobenzone, reducing the rate of photochemical degradation and ensuring that the UV-A protection curve remains flat and consistent over prolonged sun exposure.

Moreover, the highly lipophilic nature of DBT requires careful selection of cosmetic solvents and emollients to prevent crystallization during storage. Formulators typically dissolve Iscotrizinol in polar emollients such as C12-15 Alkyl Benzoate, Dibutyl Adipate, or Dicaprylyl Carbonate. Ensuring optimal solubility not only stabilizes the emulsion but also improves the sensory profile of the final product, leaving a non-greasy, lightweight texture on the skin.

About The Manufacturer

About Aogebio LLC

Founded in 2013 and headquartered in the prestigious high-tech zone of Xi'an, Xi'an Aoge Biotech Co., Ltd., along with its subsidiaries Xi'an Imaherb Biotech Co., Ltd. and Xi'an Nahanutri Biotech Co., Ltd., has established itself as a leading force in the cosmetics raw materials industry.

Our expansive cooperative factory, spanning 1,000 mu (approximately 165 acres), is equipped with state-of-the-art extraction technology. This advanced infrastructure allows us to manufacture a wide array of premium cosmetic raw materials. Our product line includes natural plant extracts specifically designed for organic cosmetics, as well as synthetic ingredients for high-end skincare formulations. These raw materials serve as the foundation for a multitude of skincare, haircare, and makeup products, ensuring superior quality and efficacy throughout the entire production process.

By implementing strict quality management pathways, our facilities bridge the gap between high-yield chemical synthesis and rigorous international standards. We leverage our geological and logistical advantages in China to deliver raw materials globally with unmatched efficiency.

View more
21+
Years of professional industry experience
50T
Cosmetic raw material capacity per month
66k+
Factory total area in square meters (66,667 m²)
Aogebio Biotech Factory View

Unrivaled Chinese Factory & Supply Chain Efficiency

How Aogebio optimizes chemical synthesis, raw material sourcing, and scale economics to benefit global cosmetic enterprises.

Vertical Integration
We source key intermediates directly within the domestic chemical cluster, insulating global buyers from supply shocks and raw material volatility.
Cost Optimization
Our advanced green solvent recycling systems and high-throughput automated reactors significantly reduce overhead costs while increasing batch yields.
Rapid Lead Times
Leveraging the infrastructure of Xi'an's high-tech logistics hub, we ensure customs clearance, documentation, and maritime/aerial transit occur without bottleneck delay.
Strict Regulatory Compliance
Every export batch complies with REACH, Chinese CSAR guidelines, and global heavy metal and microbiological limits.

Targeted Localized Application Scenarios

Different markets present distinct formulation challenges. Here is how Iscotrizinol adapts to specific geographical and product needs.

European Premium Daily SPF
High-end day creams require a luxurious, invisible finish. Iscotrizinol allows formulators to hit high UV-B protection targets without the heavy, chalky residue characteristic of inorganic oxides.
Tropical Water-Resistant Sport Lotions
Because Iscotrizinol is highly lipophilic and insoluble in water, it remains anchored to the skin barrier during sweating or water immersion, making it ideal for sports formulations.
Sensitive Skin & Clinical Dermatological Formulations
With a molecular weight of 766 Daltons, Iscotrizinol is structurally too large to penetrate the stratum corneum, significantly reducing transdermal absorption and localized skin irritation. This properties make it perfect for clinically backed sunscreens for eczema-prone or post-treatment skin.

Procurement Framework & Quality Standards for Global Brands

Key benchmarks for procurement managers, chemical importers, and formulators sourcing Iscotrizinol.

Analytical Certification & Purity Verification
Every container of Iscotrizinol from Aogebio comes with a comprehensive Certificate of Analysis (COA) containing gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) profiles proving purity exceeding 99%. Our analytical testing prevents batch inconsistencies that could alter emulsion stability and SPF values.
Packaging & Storage Longevity
Because crystalline UV filters can degrade when exposed to humidity and extreme temperatures, we package our Iscotrizinol in heavy-duty cardboard drums lined with double-layered food-grade polyethylene bags. This robust barrier stops moisture absorption and photo-initiated changes during shipping across different climate zones.

Qualifications & Honors

Our in-house lab uses advanced instruments like UPLC, HPLC, GC-MS, ICP-MS for quality control, ensuring raw materials meet strict international standards.

Aogebio Certificate 1
Aogebio Certificate 2
Aogebio Certificate 3
Aogebio Certificate 4
Aogebio Certificate 5
Aogebio Certificate 6

Why Choose Us

At Aogebio, innovation, quality, and sustainability are the bedrock of our corporate philosophy.

Innovation in R&D
We pour relentless efforts into research and development, constantly exploring novel raw materials and advanced manufacturing techniques to stay ahead in the dynamic cosmetics industry.
Quality Control
Rigorous quality control is embedded in every step of our production process, from raw material sourcing to final product delivery, guaranteeing that each item adheres to the most stringent international standards.
Sustainability
Meanwhile, we actively embrace sustainable practices, striving to minimize our environmental footprint through eco-friendly production methods and responsible sourcing.
Commitment to Excellence
This unwavering dedication enables us not only to consistently offer products of unparalleled excellence but also to contribute to the long-term, healthy development of the entire cosmetics industry.

Technical Q&A: Deep Insights for Cosmetic Chemists

Critical inquiries resolved by Aogebio's chief science officer and manufacturing engineers.

Q1: What is the maximum usage limit of Iscotrizinol (DBT) in global sun care products?
Under Annex VI of the EU Cosmetics Regulation and China's Safety and Technical Standards for Cosmetics (CSAR), the maximum authorized concentration of Diethylhexyl Butamido Triazone is 10%. In Japan, it is also approved up to 10%. For the US market, it remains an unapproved active ingredient under the historic OTC monograph, meaning it cannot be declared as an active sunscreen ingredient in OTC products sold within the United States.
Q2: How does Iscotrizinol's solubility profile affect emulsion stability?
Iscotrizinol is highly oil-soluble and virtually insoluble in water. To prevent recrystallization in emulsions, which destroys SPF efficacy and texture, it must be dissolved in polar oils like C12-15 Alkyl Benzoate, Dicaprylyl Ether, or Propylene Glycol Dicaprylate. We recommend using a ratio of at least 3 parts solvent oil to 1 part Iscotrizinol to ensure long-term physical stability in storage.
Q3: Is Iscotrizinol considered reef-safe and environmentally non-toxic?
Yes, current marine biology assessments show that Iscotrizinol does not cause the coral reef bleaching associated with older organic filters like Oxybenzone (Benzophenone-3) and Octinoxate (Ethylhexyl Methoxycinnamate). Its high molecular weight prevents absorption by marine organisms, making it a key component in eco-conscious, reef-safe sunscreen formulations.
Q4: What instruments does Aogebio use to control the heavy metal and chemical purity of Iscotrizinol?
Our quality control labs use Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to quantify trace heavy metal impurities (such as arsenic, lead, and mercury) at the parts-per-billion (ppb) level. We also use High-Performance Liquid Chromatography (HPLC) coupled with ultraviolet detectors to verify chemical purity and verify that no residual solvents are present in the final crystalline powder.

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