CAS:4065-45-6, chemically classified as Benzophenone-4 (also known as Sulisobenzone), is a highly effective, water-soluble UV absorber that plays a vital role in protecting organic substances and human skin from harmful solar radiation. Formulators utilize Benzophenone-4 to target the critical UV wavelength ranges (both UVB and short-wave UVA spectrums), preventing degradation, discoloration, and photo-oxidation in both cosmetic and industrial matrices.
Unlike oil-soluble organic filters, Benzophenone-4 contains a sulfonic acid group that guarantees exceptional solubility in water, alcohol, and glycols. This unique chemical profile makes it the go-to compound for transparent formulations, lightweight gels, and aqueous solutions where oil-phase additions are restricted.
By absorbing high-energy ultraviolet photons and releasing the energy as harmless thermal dissipation (internal conversion), CAS:4065-45-6 ensures the structural integrity of pigments, active botanicals, and synthetic polymers in final products. As regulatory frameworks become more stringent globally, verifying the sourcing lineage from qualified manufacturers is critical for high-tier cosmetic applications.
| Parameter | Specification Standard |
|---|---|
| IUPAC Name | 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid |
| Molecular Formula | C14H12O6S |
| Molecular Weight | 308.31 g/mol |
| Assay (HPLC) | Min. 99.0% |
| Appearance | Off-white to light yellow crystalline powder |
| Melting Point | Min. 140°C |
| Solubility | Highly soluble in water (>250 g/L at 20°C) |
China's chemical synthesis infrastructure offers unmatched efficiency, capacity, and quality control systems. Partnering with a vetted Chinese factory like Aogebio ensures supply chain stability and regulatory adherence.
Our production facilities benefit from direct proximity to basic petrochemical raw materials, reducing transit risks and raw material cost spikes. This vertical integration allows us to pass structural cost savings directly to global wholesale buyers.
Using advanced instrumentation such as Ultra-Performance Liquid Chromatography (UPLC), High-Performance Liquid Chromatography (HPLC), and Gas Chromatography-Mass Spectrometry (GC-MS), our factories guarantee assay purity exceeding 99% with minimal trace metal residues.
With an expansive manufacturing capacity, our partner factories can scale volume requirements seamlessly. From small trial batches for pilot cosmetic lines to monthly metric-ton container shipments, we maintain consistent physical-chemical properties across batches.
The cosmetic and specialty chemical industries are witnessing rapid changes driven by consumer demand and tightening eco-regulations. Global players are shifting focus toward multifunctional ingredients that offer formulation stability alongside high skin protection efficacy.
The global demand for high-efficacy UV filters is projected to grow substantially as consumers become more aware of the long-term cellular damage caused by solar radiation. Sun protection is no longer seasonal; it is integrated into daily moisturizers, foundation creams, and anti-aging hair treatment lines. Factories that secure premium-grade CAS:4065-45-6 with low hazard profiles are positioned to dominate B2B supply lines in the next decade.
Fully approved in the European Union (Annex VI to the Cosmetics Regulation, max concentration up to 5% expressed as acid) and recognized by the US FDA as an OTC sunscreen ingredient.
From standard skincare formulas to robust industrial polymer stabilization, Benzophenone-4 is an incredibly versatile compound. Discover its localized, high-value applications across key commercial product sectors:
Commonly integrated into sun gels, clear sun protection sprays, and daily hydrating lotions. It prevents UVB-induced sunburn and acts as a photo-stabilizer for color pigments, active vitamins, and natural botanical botanical compounds in the formula, extending shelf life.
UV radiation breaks down keratin and fades color-treated hair. CAS:4065-45-6 is formulated into shampoos, leave-in conditioners, and heat-protective hair mists. Being water-soluble, it deposits evenly without leaving oily residues on the scalp or weighed-down hair fibers.
Products packaged in clear PET or glass containers are susceptible to discoloration and oxidation when exposed to sunlight on retail shelves. Adding Benzophenone-4 directly to the bulk formulation protects sensitive colorants, active botanicals, and fragrance oils from photo-induced degradation.
High-volume cosmetic manufacturing requires more than just high-purity chemical supply. It demands rigorous documentation, logistics optimization, and consistent technical support.
Aogebio offers streamlined procurement channels for cosmetic firms, pharmaceutical developers, and industrial chemical distributors. By setting up strict raw material audits and optimizing internal shipping processes, we resolve standard international bottlenecks, including moisture contamination during ocean freight, customs clearance delays, and documentation gaps.
Founded in 2013 and headquartered in the prestigious high-tech zone of Xi'an, Xi'an Aoge Biotech Co., Ltd., along with its specialized subsidiaries Xi'an Imaherb Biotech Co., Ltd. and Xi'an Nahanutri Biotech Co., Ltd., has established itself as a leading force in the global cosmetics raw materials industry.
Our expansive cooperative factory, spanning over 1,000 mu (approximately 165 acres or 66,667 m²), is equipped with state-of-the-art chemical synthesis and extraction technologies. This advanced infrastructure allows us to manufacture a wide array of premium cosmetic raw materials, including natural plant extracts for organic cosmetics and high-purity synthetic ingredients for high-end skincare formulations. These raw materials serve as the foundation for a multitude of skincare, haircare, and makeup products, ensuring superior quality and efficacy throughout the entire production process.
Our in-house analytical laboratory utilizes cutting-edge testing equipment, including Ultra-Performance Liquid Chromatography (UPLC), High-Performance Liquid Chromatography (HPLC), Gas Chromatography-Mass Spectrometry (GC-MS), and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for strict quality control. Every batch of CAS:4065-45-6 is verified to meet international limits for heavy metals, residues, and active chemical assays.
At Aogebio, innovation, quality, and sustainability are the bedrock of our corporate philosophy, shaping how we serve our manufacturing partners globally.
We pour relentless efforts into research and development, constantly exploring novel raw materials and advanced manufacturing techniques to stay ahead in the dynamic cosmetics industry.
Rigorous quality control is embedded in every step of our production process, from raw material sourcing to final product delivery, guaranteeing that each item adheres to the most stringent international standards.
Meanwhile, we actively embrace sustainable practices, striving to minimize our environmental footprint through eco-friendly production methods and responsible sourcing.
This unwavering dedication enables us not only to consistently offer products of unparalleled excellence but also to contribute to the long-term, healthy development of the entire cosmetics industry.
Our facilities operate under strict international manufacturing systems. We maintain a robust set of certifications verifying our standards for production safety, environmental care, and cosmetic ingredient quality control.
Get expert insights on properties, regulations, stability testing, and procurement specifications for Benzophenone-4.
CAS:4065-45-6 (Benzophenone-4) acts as a secondary water-soluble UV absorber. It protects both the consumer's skin and the product itself from UV damage. In sunscreen formulations, it helps absorb UVB and short-wave UVA light. In color cosmetics, gels, and shampoos, it functions as a photostabilizer to prevent light-induced fading and structural breakdown of raw ingredients, colors, and fragrance complexes.
Under the EU Cosmetics Regulation Annex VI, Benzophenone-4 is allowed as a UV filter up to a maximum concentration of 5% (calculated as the free acid). In the United States, the FDA recognizes it as a Category I sunscreen ingredient (approved for use in OTC sunscreen formulations up to 10% in concentration). Formulators must always review target market regulations before manufacturing.
Benzophenone-3 (Oxybenzone) is highly oil-soluble and is typically incorporated into the oil phase of emulsions. Benzophenone-4 (Sulisobenzone) contains a sulfonic acid group, rendering it highly water-soluble. This allows it to be easily dissolved in the aqueous phase, making it the perfect candidate for alcohol-based styling gels, clear body sprays, hand sanitizers, and oil-free daily moisturizers.
Because Benzophenone-4 contains a sulfonic acid group, it is highly acidic in aqueous solution (pH typically ranges from 1.2 to 2.2 for a 1% solution). To avoid destabilizing other ingredients in your cosmetic base, the formula must be neutralized using an organic or inorganic base (such as Triethanolamine, Sodium Hydroxide, or Aminomethyl Propanol) to achieve a stable cosmetic pH of 5.5 to 7.0.
Our standard packaging for B2B orders of CAS:4065-45-6 is 25 kg fiber drums with double food-grade polyethylene inner bags to prevent moisture absorption. When stored in sealed containers in a cool, dry, well-ventilated area away from strong oxidizing agents, the chemical remains stable with a shelf life of up to 24 months from the manufacturing date.
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